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Endoplasmic Reticulum-associated Amyloid Beta-peptide binding protein (ERAB)

Endoplasmic Reticulum-associated Amyloid Beta-peptide binding protein (ERAB)

Cat no: E2291-53B

Supplier: United States Biological
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Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB) is a 27kD protein, member of the short-chain dehydrogenase/reductase family, it catalyses the oxidation of a wide variety of fatty acids, alcohols, and steroids. It is constitutively expressed in tissues and overexpressed in neurons affeceted in Alzheimer's disease. ERAB binds amyloid.beta and may be a determining factor in the level of cytotoxicity observed in the brain of Alzheimer's patients. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1000 Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: E2291-53B
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 1mg
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Pab
Purity: Purified by Protein G affinity chromatography.
References: Yan, S.D. et al. (1997) Nature 389,689-695. He, X.Y. et al. (1998) J. Biol. Chem. 273,10741-10746. Oppermann, U.C. (1999) FEBS Lett. 451,238-242.
Additional info: Recognizes human ERAB

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