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Endoplasmic Reticulum-associated Amyloid Beta-peptide binding protein (ERAB)

Cat no: E2291-53B

Endoplasmic Reticulum-associated Amyloid Beta-peptide binding protein (ERAB)

Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB) is a 27kD protein, member of the short-chain dehydrogenase/reductase family, it catalyses the oxidation of a wide variety of fatty acids, alcohols, and steroids. It is constitutively expressed in tissues and overexpressed in neurons affeceted in Alzheimer's disease. ERAB binds amyloid.beta and may be a determining factor in the level of cytotoxicity observed in the brain of Alzheimer's patients.\n\nApplications: \nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:1000\nWestern Blot: 1:1000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

E2291-53B

Size

1mg

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

References

Yan, S.D. et al. (1997) Nature 389,689-695. He, X.Y. et al. (1998) J. Biol. Chem. 273,10741-10746. Oppermann, U.C. (1999) FEBS Lett. 451,238-242.

Additional Info

Recognizes human ERAB

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