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Endoplasmic Reticulum Protein 57 (ERp57, GRP58, PDIA3, Protein disulfide isomerase family A, member 3 [Homo sapiens], HGNC:4606, ERp60, ERp61, GRP57, HsT17083, P58, PI-PLC, 58kD microsomal protein, endoplasmic reticulum P58, glucose regulated protein, 58k

Cat no: E2291-75

Endoplasmic Reticulum Protein 57 (ERp57, GRP58, PDIA3, Protein disulfide isomerase family A, member 3 [Homo sapiens], HGNC:4606, ERp60, ERp61, GRP57, HsT17083, P58, PI-PLC, 58kD microsomal protein, endoplasmic reticulum P58, glucose regulated protein, 58k

ERp57 (also known as Grp58), a member of the thioredoxin superfamily, is an ER protein with disulfide isomerase activity. It has been shown to increase after oncogenic transformation and to be a component of the MHC Class I peptide-loading complex.\n\nThe Grp

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SPECIFICATIONS

Catalog Number

E2291-75

Size

50ug

Applications

IP, WB

Hosts

Mouse

Reactivities

Hum, Can, NHP, Prc

Form

Supplied as a liquid in PBS, pH 7.2, 25mM sodium chloride, 5mM sodium phosphate , 0.05mM PMSF, 50% glycerol.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

References

1. Hirano, N., et al., (1994) Biochem. Biophys. Res. Commun. 204: 375-382. 2. Hughes, E.A., and Cresswell, P. (1998) Current Biology 8:709-712. 3. Murthy, M.S.R., and Pande, S.V. (1994) Biochem J. 304:31-34. 4. Murthy, M.S.R., and Pande, S.V. (1993) Mol. Cell. Biochem. 122:133-138. 5. Lee, A.S. (1981) J. Cell. Physiol. 106:119-125. 6. Mazzarella, R.A., et al., (1990) J. Biol. Chem. 265:1094-1101. \n7. Kaplitt, M.G., et al., (1993) Endocrinology (Baltimore) 133:99-104. 8. Mazzarella, R.A., et al., (1994) Arch. Biochem. Biophys. 308:454-460. 9. Alteri, F., et al., (1993) Biochem. Biophys. Res. Commun. 194:992-1000. 10. Ohtani, H., et al., (1993) Histochemistry 100:423-429. 11. Henry, M.F., and Cronan, J.E., Jr. (1992) Cell 70:671-679. 12. DiRusso, C.C., Heimert, T.L., and Metzer, A.K. (1992) J. Biol. Chem. 267:8685-8691. 13. Roncero, C. and Goodridge, A. (1992) J. Biol. Chem. 267:14918-14927. 14. Camp, L.A. and Hoffmann, S.L. (1993) J. Biol. Chem. 268:22566-22574. 15. Mobbs, C.V., Fink, G., and Pfaff, D.W. (1990) Science 247:1477-1479. 16. Barker, W.C., et al., (1990) Science 249:566-567. 17. Nigam, S.K., et al., (1994) J. Biol. Chem. 269:1744-1749. \n

Additional Info

Detects a ~58kD protein, corresponding to the apparent molecular mass of ERp57 on SDS-PAGE immunoblots, in samples from human, canine, porcine, hamster and monkey. There is no reactivity detected in mouse or rat cell lines.

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Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info
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