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Endothelin A Receptor, aa410-422 (ET-A, ET1-Specific Type Endothelin Receptor, Ednra, ETA, ETRA)

Endothelin A Receptor, aa410-422 (ET-A, ET1-Specific Type Endothelin Receptor, Ednra, ETA, ETRA)

Cat no: E3100-01A

Supplier: United States Biological
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Endothelins are a family of peptides that are potent vasoconstrictors produced by mammalian vascular endothelial cells. The receptors for endothelins are widely expressed on tissues. This sheep antibody recognizes epitopes on the cytoplasmic region of the ET(A) Receptor. The binding of this antibody does not interfere with the function of the receptor so that endothelins can interact with the receptor while the antibody is present. Cellular Localization: Plasma membrane Applications: Suitable for use in Immunofluorescence, Immunoprecipitation, Immunohistochemistry (paraffin-embedded sections) and Immunocytochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: E3100-01A
Reactivities: Human, Mouse, Sheep
Hosts: Sheep
Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation
Size: 125ug
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Wulfing P, et al., (2004) Oncol Rep. Apr;11(4):791-6. 2 Siren AL, et al., (2000) Neurochem Res. Jul;25(7):957-69. 3 Shraga-Levine Z, et al., (2000) Cell Mol Neurobiol. Jun;20(3):305-17. 4 Fernandes LB, et al., (1998) J Cardiovasc Pharmacol. 31(Suppl1):S222-4. 5 Barber DA, et al., (1996) Am J Physiol. Jan;270(1 Pt 2):H65-71.
Additional info: This antibody recognizes epitopes on the cytoplasmic side of the receptor and will not block the binding of endothelins. Therefore, the cell membrane must be permeable to the antibody. Species Crossreactivity: Crossreacts with Human, Mouse and Sheep.

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