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Endothelin B Receptor (ET-B; Nonselective Type Endothelin Receptor, Ednrb, ETB, ETRB)

Cat no: E3110-02H

Endothelin B Receptor (ET-B; Nonselective Type Endothelin Receptor, Ednrb, ETB, ETRB)

EDNRB (Endothelin B Receptor) is a member of the beta-family of rhodopsin receptors. It binds endothelin 1, 2 and 3, and is found on endothelial cells where it mediates vasodilation. Mature human EDNRB is a 7-transmembrane glycoprotein that is 416 amino acids (aa) in length. It contains a 75aa N-terminal extracellular region (aa27-101), and a 44aa C-terminal cytoplasmic domain. There are three EDNRB variants that affect aa27-101. One shows a 90aa N-terminal extension, a second shows the same 90aa N-terminal substitution coupled with a deletion of aa268-398, and a third shows proteolytic cleavage between Arg64-Ser65. Over aa27-101, human EDNRB shares 67% and 97% aa identity with mouse and canine EDNRB, respectively.\n\nApplications: \nSuitable for use in Flow Cytometry, ELISA, Western Blot and Immunocytochemistry. Other applications not tested.\n\nRecommended Dilutions:\nFlow Cytometry: 2.5ug/10e6 cells using A172 human glioblastoma cell line.\nWestern Blot: 1ug/ml on HEK293 human embryonic kidney cell line, A172 human glioblastoma cell line and Raji human Burkitt

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SPECIFICATIONS

Catalog Number

E3110-02H

Size

100ug

Applications

ELISA, FC, ICC, WB

Hosts

Sheep

Reactivities

Hum

Form

Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

Additional Info

Recognizes human Endothelin B Receptor.

Read more on Supplier website

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info

Applications

FC

Hosts

Mouse

Reactivities

Hum

More info
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