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Endothelin B Receptor (ET-B; Nonselective Type Endothelin Receptor, Ednrb, ETB, ETRB)

Endothelin B Receptor (ET-B; Nonselective Type Endothelin Receptor, Ednrb, ETB, ETRB)

Cat no: E3110-02H

Supplier: United States Biological
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EDNRB (Endothelin B Receptor) is a member of the beta-family of rhodopsin receptors. It binds endothelin 1, 2 and 3, and is found on endothelial cells where it mediates vasodilation. Mature human EDNRB is a 7-transmembrane glycoprotein that is 416 amino acids (aa) in length. It contains a 75aa N-terminal extracellular region (aa27-101), and a 44aa C-terminal cytoplasmic domain. There are three EDNRB variants that affect aa27-101. One shows a 90aa N-terminal extension, a second shows the same 90aa N-terminal substitution coupled with a deletion of aa268-398, and a third shows proteolytic cleavage between Arg64-Ser65. Over aa27-101, human EDNRB shares 67% and 97% aa identity with mouse and canine EDNRB, respectively. Applications: Suitable for use in Flow Cytometry, ELISA, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilutions: Flow Cytometry: 2.5ug/10e6 cells using A172 human glioblastoma cell line. Western Blot: 1ug/ml on HEK293 human embryonic kidney cell line, A172 human glioblastoma cell line and Raji human Burkitt
Catalogue number: E3110-02H
Reactivities: Human
Hosts: Sheep
Applications: ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
Size: 100ug
Form: Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human Endothelin B Receptor.

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