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eNOS (Nitric Oxide Synthase, Endothelial, Constitutive NOS, cNOS, EC-NOS, Endothelial NOS, Nitric Oxide Synthase 3, NOS Type III, NOSIII, NOS3)

eNOS (Nitric Oxide Synthase, Endothelial, Constitutive NOS, cNOS, EC-NOS, Endothelial NOS, Nitric Oxide Synthase 3, NOS Type III, NOSIII, NOS3)

Cat no: E3010-84F

Supplier: United States Biological
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Endogenous Nitric Oxide (NO) is a diffusible multifunctional second messenger that has been implicated in numerous physiological functions in mammals, such as blood vessel dilation, immune response and synaptic transmission enhancement. The NO is derived from L-arginine as the product of a complex enzymatic reaction catalyzed by a family of three NO synthase (NOS) proteins: nNOS (type I), iNOS (Type II), eNOS (type III). The endothelial NOS (eNOS) plays a critical role in controlling vascular tone, platelet aggregation, and cardiac myocyte function. It is strongly expressed in malignant mesothelioma, but is not associated with expression of vascular endothelial growth factor (VEGF) and its receptors. This phenomenon is different from what has been shown in non-neoplastic endothelial cells. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E3010-84F
Reactivities: Bovine
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Bredt, D et al. Annu Rev Biochem 63, 175 (1994). 2. Nathan, C. et al. J Biol Chem 269, 13725 (1994). 3. Loscalzo, J. et al. Prog Cordiovasc Dis 38, 87 (1995). 4. Soini, Y. et al. Histopathology 39, 179 (2001).
Additional info: Recognizes bovine NOS.

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