Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.
Melting Point:
158-160C
Solubility:
Chloroform
Method for Determining Identity:
1H NMR Spectroscopic Analysis
TLC Conditions:
SiO2: Dichloromethane: Methanol: NH4OH; 9:1:0.1; Visualized with naked eye and UV; Single spot; Rf=0.4.
Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.