Enzastaurin, Free Base

Supplier:

United States Biological

Cat no: E3317-75

Enzastaurin, Free Base

Enzastaurin inhibits PKCb, PKCa, PKCy and PKCe with IC50's of 0.006, 0.039, 0.083 and 0.110uM, respectively. Enzastaurin apparently inhibits tumor growth via multiple mechanisms: suppression of tumor cell proliferation, induction of tumor cell apoptosis and inhibition of tumor-induced angiogenesis.\n\nSolubility:\nSoluble in DMSO at 7.1mg/ml with warming; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.\n\nStorage and Stability:\nMay be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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SPECIFICATIONS

Catalog Number

E3317-75

Size

10mg

Form

Supplied as a red-orange powder.

Purity

~99%

References

1. Graff, J.R., et al. \"The protein kinase Cb-selective inhibitor, enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts.\" Cancer Res. 65:7462-7469 (2005). 2. Rizvi, M.A., et al. \"Enzastaurin (LY317615), a protein kinase Cb inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines.\" Mol. Cancer Ther. 5:1783-1789 (2006). 3. Moreau, A.S., et al. \"Protein kinase C inhibitor enzastaurin induces in vitro and in vivo antitumor activity in Waldenstr

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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