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EP400 (E1A-binding Protein p400, CAG Repeat Protein 32, Domino Homolog, hDomino, Trinucleotide Repeat-containing Gene 12 Protein, p400 kDa SWI2/SNF2-related Protein, CAGH32, KIAA1498, KIAA1818, TNRC12, DKFZP434I225, FLJ42018, FLJ45115, P400)

Cat no: 126357

EP400 (E1A-binding Protein p400, CAG Repeat Protein 32, Domino Homolog, hDomino, Trinucleotide Repeat-containing Gene 12 Protein, p400 kDa SWI2/SNF2-related Protein, CAGH32, KIAA1498, KIAA1818, TNRC12, DKFZP434I225, FLJ42018, FLJ45115, P400)

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nAA Sequence:\nQVHQRIAELRKAGLWSQRRLPKLQEAPRPKSHWDYLLEEMQWMATDFAQERRWKVAAAKKLVRTVVRHHEEKQLREERGKKEEQSRLRRIAASTAREIECFWSNIEQV\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

126357

Size

100ug

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG2a,k

Additional Info

Recognizes human EP400.

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