Ephrin B3, Recombinant, Human (EFNB3, Ephrin B3 (EFL6, EPH-related receptor transmembrane ligand ELK-L3, EPH-related receptor tyrosine kinase ligand 8, Ephrin-B3, EPLG8, LERK8)

Ephrins are the ligands which bind to the Eph receptor subfamily, the largest group of the receptor tyrosine kinase family. Both ephrins and Eph receptors are broadly expressed through the ectoderm, mesoderm, and endoderm of vertebrate embryos. Two classes of ephrins exist: Class A ephrins are tethered to the membrane by a GPI linkage and bind primarily to EphA receptors; Class B ephrins contain a membrane-spanning region and bind predominantly to EphB receptors.\n\nApplications:\n

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SPECIFICATIONS

Catalog Number

E3372-02

Size

2ug

Form

Supplied as a liquid in 50mM Tris-acetate, pH 7.5, 1mM EDTA and 20% glycerol.

Purity

On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 47kD

References

1. Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth. Proc Natl Acad Sci USA 2005 Jul 26;102(30):10694-9. 2. Characterization of the kinase domain of the ephrin-B3 receptor tyrosine kinase using a scintillation proximity assay. Assay Drug Dev Technol 2003 Aug;1(4):555-63. 3. Ephrin-B3-EphA4 interactions regulate the growth of specific thalamocortical axon populations in vitro. Eur J Neurosci 2002 Sep;16(6):1168-72. 4. Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control. Genes Dev 2001 Apr 1;15(7):877-88. 5. Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline. Neuron 2001 Jan;29(1):85-97. 6. Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube. Oncogene 1998 Jan 29;16(4):471-80.