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Epidermal Growth Factor Receptor, aa672-1210, Recombinant, Human (erbB, EGFR)

Cat no: E3375-17G

Epidermal Growth Factor Receptor, aa672-1210, Recombinant, Human (erbB, EGFR)

EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, 02, 03, -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF- ), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head, neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas. \n\nThis recombinant human EGFR comprises amino acids 672-1210 of human EGFR (Accession #P00533), fused with a GST-tag at the N-terminus with thrombin cleavage sites and has a MW of 89.171kD.\n\nApplications:\nSuitable for use in ELISA, Inhibition Assays and Western Blot. Other applications not tested. \n\nSpecific Activity: \n30pmol/ug x min\n\nStorage and Stability:\nStore -20 degrees C to -70 degrees C. Stable for 12 months. Please avoid freeze-thaw cycles.

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SPECIFICATIONS

Catalog Number

E3375-17G

Size

5ug

Form

Supplied as a sterile-filtered liquid in 50mM HEPES, pH 7.5, 100mM sodium chloride, 5mM DTT, 15mM reduced glutathione and 20% glycerol.

Purity

Purified.

References

1. Clin Cancer Res 2006 Jul 1;12(13):4103-4111. 2. Genes Dev 2006 Jul 1;20(13):1817-1828. 3. Cell Stress Chaperones 2006 Summer;11(2):135-47. 4.Dev Biol 2006 Jun 2, 5.Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2006 Jul;22(4):466-8. 6.Cancer J 2006 May-Jun;12(3):229-36.

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