The EGFR is a tyrosine protein kinase and has 2 components of different molecular weight; both contain phosphotyrosine and phosphothreonine. It localizes in the 7p13-q22 region of chromosome. EGFR is a kinase that attaches phosphate groups to tyrosine residues in proteins. Binding of EGF to the EGFR leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation. The EGFR has been reported in endomrtrium, fetus, kidney, plasma and thyroid gland. Defects in EGFR are associated with lung cancer. Four named isoforms are produced by alternative splicing.
Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (paraffin): 2.5ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control:
Ovarian carcinoma
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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