Epidermal Growth Factor Receptor (erbB, EGFR)

Cat no: E3375-01F

Supplier: United States Biological

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Description
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EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1,-2,-3-4 or HER-1,-2,-3-4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Paraffin sections): 2.5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	E3375-01F
Reactivities:	Human
Hosts:	Rabbit
Applications:	Immunohistochemistry
Size:	50ug
Form:	Supplied as a liquid in PBS, 0.1% sodium azide.
P type:	Pab
Purity:	Purified by immunoaffinity chromatography.
Alternative names:	EC=2.7.10.1, ERBB1, MENA
Additional info:	Recognizes Human Epidermal Growth Factor Receptor (EGFR). Species Crossreactivity: Human.

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Epidermal Growth Factor Receptor (erbB, EGFR)

Cat no: E3375-01F

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