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Epidermal Growth Factor Receptor (erbB, EGFR)

Epidermal Growth Factor Receptor (erbB, EGFR)

Cat no: E3375-01F1

Supplier: United States Biological
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The EGF receptor (EGFR), a 180kD transmembrane tyrosine kinase, is part of the ErbB family which mediate ligand induced signaling as heterodimers. Ligand binding results in activation of the intrinsic kinase activity and autophosphorylation on tyrosine residues within and surrounding the kinase domain. The phospho-tyrosine residues serve as docking sites for adapter proteins that nucleate signaling complexes that result in the activation of the Ras, PI-3 kinase and PLC-g pathways. EGFR, which transduces the biological effects of EGF and TGF-a, is frequently over-expressed in solid tumors. Applications: Suitable for use in ELISA, Western Blot and . Other applications not tested. Recommended Dilution: ELISA: 1:10,000 Western Blot: 1:500 Immunofluorescence: 1:1,000 Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: E3375-01F1
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunofluorescence, Western Blot
Size: 100ul
Form: Supplied as a lyophilized powder. Reconstitute in 100ul ddH2O.
P type: Pab
Purity: Serum
References: 1. Manneck, H.E., et al., (1993), "Enzyme-linked Immunosorbent Assay for the Determination of Epidermal Growth Factor Receptor", Klin. Lab., 39:177-182.
Additional info: Recognizes human EGFR.

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