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Epidermal Growth Factor Receptor (Internal Domain) (Biotin)

Epidermal Growth Factor Receptor (Internal Domain) (Biotin)

Cat no: E3375-23A

Supplier: United States Biological
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The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 1:50 Optimal dilutions to be determined by the researcher. Hybridoma: NS1 myeloma cells with spleen cells from Balb/c mice. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: E3375-23A
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry
Conjugates: Biotin
Size: 250ug
Form: Supplied as a liquid in 0.01M potassium phosphate, 0.15M sodium chloride, pH7.25, 2mM EDTA, 1% BSA, 0.1% sodium azide. Labeled with Biotin.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein G affinity chromatography.
References: 1. Berger, S.M., et al., (1987), J. of Pathology, 152:297,2. Downward, J., et al., (1984), Nature, 311:483,3. Gullick, W.J., et al., (1985), EMBP J., 4:2869,4. Gullick, W.J., et al., (1986), Cancer Research, 46:285, 5. Gullick, W.J., et al., (1991), Br. Med. Bulletin, 47:87.
Additional info: Recognizes the internal domain with an epitope between aa985-996 from the complete EGF receptor sequence of 1206aa.

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