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Epidermal Growth Factor Receptor, phosphorylated (Tyr1016) (erbB, EGFR, EC=2.7.10.1, ERBB, ERBB1, MENA)

Epidermal Growth Factor Receptor, phosphorylated (Tyr1016) (erbB, EGFR, EC=2.7.10.1, ERBB, ERBB1, MENA)

Cat no: E3375-16D

Supplier: United States Biological
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Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR is encoded by the cellular oncogene cerbB1. EGFR has an extracellular ligand binding domain, a single transmembrane region, and cytoplasmic domain which is composed of a tyrosine kinase domain and a carboxy terminal domain. The carboxy terminal domain contains at least four tyrosine autophosphorylation sites. EGFR overexpression in tumors indicates poor prognosis. EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma. Cellular Localization: Cell Membrane and Secreted Applications: Suitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: E3375-16D
Reactivities: Human, Rat
Hosts: Rabbit
Applications: ELISA, Immunoprecipitation, Western Blot
Size: 50ug
Form: 0.02% Proclin, PBS. pH 7.4
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: EC=2.7.10.1, ERBB, ERBB1, MENA
References: 1. Wells A (1999) Int J Biochem Cell Biol 31:637-43. 2. Ullrich A & Schlessinger J (1990) Cell 61:203-12. 3. Ullrich A et al. (1984) Nature 309:418-25.
Additional info: This antibody is specific for EGFR phosphorylated on Tyrosine 1016. EGFR phosphorylated at sites other than Tyrosine 1016 does not cross react. Species Crossreactivity: Crossreacts with Human and Rat.

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