EPM2A (Laforin, Lafora PTPase, LAFPTPase)

Supplier:

United States Biological

Cat no: E3384-75K

EPM2A (Laforin, Lafora PTPase, LAFPTPase)

EPM2A:Laforin is a novel dual-specificity phosphatase which associates with polyribosomes and belongs to the protein-tyrosine phosphatase family. Two isoforms of Laforin are reported which have alternate C termini and a common segment that consists of a carbohydrate-binding module and a dual-specificity protein phosphatase domain. Laforin plays an important role in the regulation of glycogen metabolism, prevents the formation of polyglucasans, and hydrolyze phosphotyrosine and phosphoserine:threonine substrates. Malin, a ubiquitin ligase, helps in regulation of Laforin protein concentration. Laforin not only interacts with itself but also with PPP1R5, HIRIP5 and EPM2AIP1. Mutations in the gene encoding EPM2A have been associated with myoclonic epilepsy type 2 (EPM2), also known as Lafora disease, an autosomal recessive and severe form of adolescent-onset progressive epilepsy. Multiple transcript variants of Laforin are expressed in most of the tissues, including brain.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.25-0.5ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHuman, mouse and rat heart lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

E3384-75K

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Bov

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Chan, EM. et al. Hum. Molec. Genet. 13:1117-1129 (2004). 2. Ganesh, S. et al. Hum. Molec. Genet. 9:2251-2261 (2000). 3. Gentry, MS. et al. Proc. Nat. Acad. Sci. 102:8501-8506 (2005).

Additional Info

Recognizes human EPM2A. Species Crossreactivity: bovine. Species sequence homology: chicken, canine, mouse, rat, xenopus.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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