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EPS15R (Epidermal Growth Factor Receptor Substrate 15-like 1, Eps15-related Protein)

EPS15R (Epidermal Growth Factor Receptor Substrate 15-like 1, Eps15-related Protein)

Cat no: E3439-45B

Supplier: United States Biological
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EPS15 and EPS15R are substrates of the epidermal growth factor (EGF) receptor kinase that are characterized by the presence of a protein:protein interaction domain, the EH domain, and by their ability to bind to the clathrin adaptor protein complex adaptor protein 2. Evidence suggests that eps15 and eps15R are involved in endocytosis (1). The most striking difference between these two related proteins is that Eps15R is also found in the nucleus, whereas Eps15 is excluded from this compartment at steady state (2). Eps15R plays a key role in clathrin-mediated endocytosis of transmembrane receptors. Using a mutational approach, it has been found that the second ubiquitin-interacting motif (UIM) of Eps15 and Eps15R is essential for their ubiquitination (3). Applications: Suitable for use inFlow Cytometry, Western Blot, Immunocytochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:10,000-20,000 Immunocytochemistry: 1:100-250 Flow Cytometry: 1:20 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: E3439-45B
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Flow Cytometry, Immunocytochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Carbone R, et al. Cancer Res., 57(24):5498-504, 1997. 2. Poupon V, et al. J Biol Chem, 277(11):8941-8, 2002. 3. Klapisz E, et al. J Biol Chem, 277(34):30746-53, 2002.
Additional info: Recognizes human EPS15R.

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