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ERAS (GTPase ERas, E-Ras, Embryonic Stem Cell-expressed Ras, HRAS2, HRASP)

ERAS (GTPase ERas, E-Ras, Embryonic Stem Cell-expressed Ras, HRAS2, HRASP)

Cat no: E2291-63

Supplier: United States Biological
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The human ERAS gene was initially reported as a processed pseudogene (HRasp, Ha-Ras2), with several base substitutions in coding regions, but was more recently described as potentially encoding a functional human ERAS protein. The ERAS oncogene supports the tumorigenic growth of embryonic stem cells by producing a constitutively active Ras protein. ERAS protein has less than 50 identity with H-Ras, another member of Ras family but the key domains essential for Ras function are highly conserved. The protein also contains amino-acid residues identical to those present in active mutants of Ras and causes oncogenic transformation in NIH 3T3 cells. Human ERAS gene is localized in the chromosomal region Xp11.23. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (formalin fixed paraffin embedded): 1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E2291-63
Reactivities: Human, Rat
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Takahashi, K. et al. Nature. 423:541-545 (2003). 2. Takashi, K. et al. Stem Cells. 23:1535-1540 (2005).
Additional info: Recognizes human ERAS. Species Crossreactivity: rat. Species sequence homology: mouse.

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