ErbB1 (Epidermal growth factor receptor, EGFR, ErbB-1)

Supplier:

United States Biological

Cat no: 167726

ErbB1 (Epidermal growth factor receptor, EGFR, ErbB-1)

Epidermal growth factor receptor (EGFR; ErbB-1) is a 170-kDa transmembrane glycoprotein encoded by the HER1 proto-oncogene. It belongs to the EGFR family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her3 (ErbB-3) and Her4 (ErbB-4). ErbB-1 is expressed on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha (TGFalpha). Growth factor binding to the extracellular domain of ErbB-1 induces formation of homo-and heterodimers with another member of the ErbB receptor family. The EGFR signaling pathway is one of the most important pathways that regulate growth, survival, proliferation and differentiation in mammalian cells, while over-expression of ErbB-1 have been associated with a number of cancers, including lung cancer and glioblastoma (2,3). \n\nApplications: \nSuitable for use in Flow Cytometry and ELISA Other applications not tested.\n\nRecommended Dilution:\nFlow Cytometry: 1.2ug/10e6 cells\nELISA: 1:200-1:400\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

167726

Size

100ug

Applications

FC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

References

1. Normanno N, Bianco C, Strizzi L, Mancino M, Maiello MR, De Luca A, Caponigro F and Salomon DS (2005). The ErbB receptors and their ligands in cancer: an overview. Curr Drug Targets 6(3):243-57 2. Harari PM (2004). Epidermal growth factor receptor inhibition strategies in oncology. Endocr Relat Cancer. 11(4):689-708

Additional Info

Recognizes human ErbB1. Recognizes the complete native protein expressed on transfected mammalian cells.

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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