ERBB2 (6C2) Antibody

Cat no: 253071

Supplier: ABBIOTEC

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Description
Additional Information

ERBB2 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 2) is a neuro/glioblastoma derived oncogene homolog. It is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overe, Xenopus/Amphibian,pression of this gene has been reported in numerous cancers, including breast and ovarian tumors.

Catalogue number:	253071
Reactivities:	Human
Applications:	Immunofluorescence, Immunohistochemistry
Size:	0.1 ml
Accession:	P04626
Antigen:	Purified recombinant fragment of human ERBB2 (aa750-987) e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	6C2
Additional info:	Receptor tyrosine protein kinase erbB2; p185erbB2; v-erbB-2; Neu proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; ERBB2; HER2; NEU; NGL