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ERBB2 (6C2B) Antibody
ABBIOTEC

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ABBIOTEC

Cat no: 252774

ERBB2 (6C2B) Antibody

ERBB2 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 2) is a neuro/glioblastoma derived oncogene homolog (avian). It is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overe, Xenopus/Amphibian,pression of this gene has been reported in numerous cancers, including breast and ovarian tumors.

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SPECIFICATIONS

Catalog Number

252774

Size

0.1 ml

Applications

IHC

Reactivities

Hum

Format

Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

P Type

Mouse Monoclonal Antibody

Antigen

Purified recombinant fragment of human ERBB2 (aa750-987) e, Xenopus/Amphibian,pressed in E. coli.\r<br>

Isotype

Mouse IgG1

Accession

P04626

Clonality

6C2B12

Additional Info

Receptor tyrosine protein kinase erbB2; p185erbB2; v-erbB-2; Neu proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; MLN 19; ERBB2; HER2; NEU; NGL

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