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ErbB2 (c-erbB2, HER2, neu Oncoprotein)

ErbB2 (c-erbB2, HER2, neu Oncoprotein)

Cat no: E3451-25N

Supplier: United States Biological
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Human Her2/neu (also known as c-erbB-2) proto-oncogene is expressed at the cell surface of a range of tumor cells. It is an essential component of a neuregulin-receptor complex, althought neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin. In many types of tumor Her2/neu expression is related to poor prognosis, with an increased risk of metastasis. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry: For paraffin sections, antigen retrieval is not needed but it may optimiz staining. Also good with frozen sections. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E3451-25N
Hosts: Rat
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified
Alternative names: C-ERBB-2, EC=2.7.10.1, ERBB2, HER-2, HER-2/NEU, NEU, NGL, P185ERBB2, TKR1
References: 1. Dean CJ et al. (1993) Cell Biophys 22:111-27. 2. Styles JM et al. (1990) Int J Cancer 45:320-4.
Additional info: Recognizes epitope E of human ErbB2 (CD340) at ~77kD.

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