Home  >  Products  >  ErbB2 (Receptor Tyrosine-protein Kinase erbB-2, Metastatic Lymph Node Gene 19 Protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine Kinase-type Cell Surface Receptor HER2, CD340, p185erbB2, HER2, MLN19, NEU, NGL)
ErbB2 (Receptor Tyrosine-protein Kinase erbB-2, Metastatic Lymph Node Gene 19 Protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine Kinase-type Cell Surface Receptor HER2, CD340, p185erbB2, HER2, MLN19, NEU, NGL)

ErbB2 (Receptor Tyrosine-protein Kinase erbB-2, Metastatic Lymph Node Gene 19 Protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine Kinase-type Cell Surface Receptor HER2, CD340, p185erbB2, HER2, MLN19, NEU, NGL)

Cat no: E3451-27U

Supplier: United States Biological
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The ErbB-2 (HER-2/neu) proto-oncogene encodes a 185kD transmembrane receptor protein. It has partial homology with the epidermal growth factor (EGF) receptor and shares intrinsic tyrosine kinase activity with the receptor. ErbB-2 heterodimerizes with the EGF receptor, ErbB-3 receptor, and the ErbB-4 receptor. In human breast and ovarian cancers the receptor is activated through amplification and over-expression of the wild-type gene. This alteration occurs in 25%-30% of cases and is associated with a poor prognosis. The poor prognosis of ovarian and breast cancer patients associated with ErbB-2-mediated high rate of tumor cell proliferation. ErbB-2 may play a role in the genesis of human gastric, endometrial and salivary gland cancers. The concentration of ErbB-2 protein in serum can be a sensitive indicator for prognosis of the gastric carcinoma that expressed ErbB-2. ErbB-2 oncoprotein is detectable in adenocarcinomas as well as in transitional cell carcinomas. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E3451-27U
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Coussens L. et al. Science 230,1132 (1985). 2. Cobleigh, M. et al. J. Clin. Oncol. 17, 2639(1999). 3. Castilla-Guerra L. et al. Histopathology 31, 144 (1997). 4. Yonemura, Y. et al. Cancer 67, 2914 (1991).
Additional info: Recognizes human c-ErbB-2.

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