ErbB2 (Receptor Tyrosine-protein Kinase erbB-2, p185erbB2, CD340, HER2, HER-2, HER-2/neu, Metastatic Lymph Node Gene 19 Protein, MLN 19, MLN19, NEU, NGL, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, TKR1, Tyrosine Kinase-type Cell Surface Receptor HER2)

A novel v-erb-B-related gene, c-erb-B-2, which has been identified in the Human genome, maps to Human chromosome 17 at q21, encodes a polypeptide with a kinase domain. The c-erb-B-2 gene is conserved in vertebrates. Its over-expression is sometimes involved in the neoplastic process. It is an essential component of a neuregulin-receptor complex. Alternative splicing results in several additional transcript variants. It has no ligand binding domain of its own but it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 1:25-1:50\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nBreast carcinoma\n\nCellular Localization: \nCell membrane\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

E3451-25T

Size

500ul

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in 0.05% sodium azide.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Yamamoto et al. Nature 319: 230, 1986. 2. Fukushige et al. Mol Cell Biol 6: 955, 1986. 3. Schechter et al. Science 229: 976, 1985. 4. Wright et al. Cancer Res 49: 2087, 1989. 5. Haerslev et al. Applied Immunohistochemistry 1: 223, 1993.

Additional Info

Recognizes human c-erbB-2.

Alternative Names

EC=2.7.10.1, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian)