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ERBB3 (2F9) Antibody

ERBB3 (2F9) Antibody

Cat no: 252905

Supplier: ABBIOTEC
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ERBB3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3) is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overe, Xenopus/Amphibian,pression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form.
Catalogue number: 252905
Reactivities: Human
Applications: Immunofluorescence
Size: 0.1 ml
Accession: P21860
Antigen: Purified recombinant e, Xenopus/Amphibian,tracellular fragment of human ERBB3 (aa22-369) fused with hIgGFc tag e, Xenopus/Amphibian,pressed in HEK293 cells.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type: Mouse Monoclonal Antibody
Isotype: Mouse IgG1
Clonality: 2F9
Additional info: Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; HER3 ;ERBB3
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