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MtoZ Biolabs

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ERBB3 (2F9) Antibody
ABBIOTEC

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ABBIOTEC

Cat no: 252905

ERBB3 (2F9) Antibody

ERBB3 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 3) is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overe, Xenopus/Amphibian,pression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form.

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SPECIFICATIONS

Catalog Number

252905

Size

0.1 ml

Applications

IF

Reactivities

Hum

Format

Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

P Type

Mouse Monoclonal Antibody

Antigen

Purified recombinant e, Xenopus/Amphibian,tracellular fragment of human ERBB3 (aa22-369) fused with hIgGFc tag e, Xenopus/Amphibian,pressed in HEK293 cells.

Isotype

Mouse IgG1

Accession

P21860

Clonality

2F9

Additional Info

Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; HER3 ;ERBB3

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