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erbB4 (c-erbB4, HER4)

erbB4 (c-erbB4, HER4)

Cat no: E3451-40M

Supplier: United States Biological
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erbB4/HER4 is the fourth member of the human epidermal growth factor receptor (EGFR) family that is frequently overexpressed in a variety of aggressive epithelial carcinomas. Its extracellular domain is most similar to the orphan receptor HER3, whereas its cytoplasmic kinase domain exhibits 79% and 77% identity with EGFR and HER2, respectively. HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain and cerebellum. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 detects erbB-4 on 10ug of A431 lysates. Immunohistochemistry: formalin-fixed, paraffin-embedded sections. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E3451-40M
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.6, 0.01% sodium azide.
P type: Mab
Isotype: IgG2b
Purity: Purified
References: 1. Srinivasan, R., et al. (1998). Journal of Pathology. 185(3): 236-45.
Additional info: Recognizes human c-erB-4/Her 4 cytoplasmic domain of the protein (residues 1250-1264), a member of the EGF receptor (type 1) family involved in cell growth regulation. Expression or function may be altered in human cancers. Species Crossreactivity: rat.

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