Home  >  Products  >  ErbB4 (c-erbB4, HER4, MGC138404, p180erbB4, Proto-oncogene-like Protein c-ErbB-4, Receptor Tyrosine-protein Kinase erbB-4, Tyrosine Kinase-type Cell Surface Receptor HER4)
ErbB4 (c-erbB4, HER4, MGC138404, p180erbB4, Proto-oncogene-like Protein c-ErbB-4, Receptor Tyrosine-protein Kinase erbB-4, Tyrosine Kinase-type Cell Surface Receptor HER4)

ErbB4 (c-erbB4, HER4, MGC138404, p180erbB4, Proto-oncogene-like Protein c-ErbB-4, Receptor Tyrosine-protein Kinase erbB-4, Tyrosine Kinase-type Cell Surface Receptor HER4)

Cat no: E3451-40Q

Supplier: United States Biological
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ERBB-4 receptor tyrosine kinase is activated by neuregulins, nrg- 2, nrg-3, heparin-binding egf-like growth factor, betacellulin and ntak to regulate cell proliferation and differentiation. Several isoforms of the ERBB-4 receptor tyrosine kinase have been identified and differ functionally in their response to phorbol ester: they represent cleavable and noncleavable forms of the receptor. These isoforms are differentially expressed in tissues. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 32ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human glomerulus and renal tubular epithelium in cortex Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E3451-40Q
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS, 0.1% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: EC=2.7.10.1, v-erb-a Erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian)
References: 1. Pediatr Pulmonol 2006 Oct.: ErbB receptor dimerization, localization, and co-localization in mouse lung type II epithelial cells. Zscheppang K, Korenbaum E, Bueter W, Ramadurai SM, Nielsen HC, and Dammann CE. 2. Mol Psychiatry 2006 Oct.: Neuregulin 1 (8p12) and childhood-onset schizophrenia: susceptibility haplotypes for diagnosis and brain developmental trajectories. Addington AM, Gornick MC, Shaw P, Seal J, Gogtay N, Greenstein D, Clasen L, Coffey M, Gochman P, Long R, and Rapoport JL. 3. J Biol Chem 2006 Oct.: Negative constraints underlie the ErbB specificity of EGF-like growth factors. van der Woning SP, van Rotterdam W, Nabuurs SB, Venselaar H, Jacobs-Oomen S, Wingens M, Vriend G, Stortelers C, and van Zoelen EJ. 4. Cell 2006 Oct. 127:185-97 Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Sardi SP, Murtie J, Koirala S, Patten BA, and Corfas G 5. Cell 2006 Oct. 127:45-8 Nuclear signaling by receptor tyrosine kinases: the first robin of spring. Schlessinger J, and Lemmon MA.
Additional info: Recognizes human ERBB-4.

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