ERCC4 (Excision Repair Cross Complement Group 4)

XPF/ERCC4 is suggested to play a role in the repair of DNA double-strand breaks (DSB), homologous recombination, and gene conversion via single-strand annealing (SSA). XPF/ERCC4 is an endonuclease that incises 5-prime DNA. Defects in XPF/ERCC4 cause xeroderma pigmentosum VI (XP6) an autosomal recessive disease characterized by hypersensitivity to sunlight and a predisposition to skin cancer as well as neurological abnormalities. Defects in XPF/ERCC4 are also responsible for XFE progeroid syndrome, a syndrome characterized by dwarfism, cachexia, and microcephaly. Alternate names for XPF/ERCC4 include DNA repair endonuclease XPF, DNA excision repair protein ERCC-4, DNA-repair protein complementing XP-F cells, xeroderma pigmentosum group F-complementing protein, ERCC11, and RAD1.\n\nApplications: \nSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

E3451-53

Size

100ul

Applications

IP, WB

Hosts

Rabbit

Reactivities

Hum

Form

Tris-buffered saline, 0.1% BSA

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Additional Info

Species Crossreactivity: Human. Other species not yet tested.

Alternative Names

ERCC-4, Excision Repair Cross-complementing Rodent Repair Deficiency Complementation Group 4, RAD1, XPF, Xeroderma Pigmentosum Complementation Group F