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ERK 1/2 (phospho Tyr222/205) Polyclonal Antibody

Cat no: ABP50442

ERK 1/2 (phospho Tyr222/205) Polyclonal Antibody

MAPK1 encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this MAPK1.

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SPECIFICATIONS

Catalog Number

ABP50442

Size

30micro l, 100micro l, 200micro l

Applications

ELISA, IF, IHC-F, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Gene Id

5594/5595

Isotype

Rabbit IgG

Accession

P28482/P27361

Clonality

Polyclonal

Concentration

1 mg/ml

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