ERVWE1, CT (ERVW-1, ERVWE1, HERV-W_7q21.2 provirus ancestral Env polyprotein, Endogenous retrovirus group W member 1, Env-W, Envelope polyprotein gPr73, Enverin, HERV-7q Envelope protein, HERV-W envelope protein, Syncytin, Syncytin-1, Surface protein, gp5

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze R-Phycoerythrin conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

035224-PE

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to R-Phycoerythrin (R-PE).

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :\nOppelt, P., et al. Gynecol. Endocrinol. 25(11):741-747(2009)\nGimenez, J., et al. DNA Res. 16(4):195-211(2009)\nLarsen, J.M., et al. Cancer Lett. 280(1):44-49(2009)\nNoorali, S., et al. Appl. Immunohistochem. Mol. Morphol. 17(4):319-328(2009)

Additional Info

Human

Alternative Names

ERVW-1, ERVWE1, HERV-W_7q21.2 provirus ancestral Env polyprotein, Endogenous retrovirus group W member 1, Env-W, Envelope polyprotein gPr73, Enverin, HERV-7q Envelope protein, HERV-W envelope protein, Syncytin, Syncytin-1, Surface protein, gp50, Transmembrane protein, gp24