Erythropoietin Receptor, phosphorylated (Tyr485) (EPOr)

Cat no: E3455-23B

Supplier: United States Biological

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Description
Additional Information

Erythropoietin (Epo) is a hematopoietic cytokine that is a potent regulator of the viability, differentiation and proliferation of erythroid progenitor cells (1, 3).Epo acts on its target cells by inducing homodimerization of the erythropoietin receptor (EpoR), thereby triggering intracellular signaling cascades. The EpoR encompasses eight tyrosine motifs on its cytoplasmic tail that have been shown to recruit a number of regulatory proteins (1).EpoR shares conserved features in its extracellular and cytoplasmic domains with other family members of cytokine and growth factor receptors (2).Alterations of the Epo/EpoR system have recently been shown to be involved in the pathogenesis of familial erythrocytosis and polycythaemia vera (PV) (3). Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:10,000-1:50,000 Immunoprecipitation: 1:20 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.

Catalogue number:	E3455-23B
Reactivities:	Human
Hosts:	Rabbit
Applications:	Immunoprecipitation, Western Blot
Size:	100ul
Form:	Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type:	Mab
Isotype:	IgG
Purity:	Supernatant
Alternative names:	MGC138358
References:	1. Ho?rtner M, et al. Eur J Biochem. 269(10):2516-26, 2002 2. Middleton SA, et al. J Biol Chem. 271(24):14045-54, 1996 3. Hess G, et al. Br J Haematol. 88(4):794-802, 1994
Additional info:	Recognizes human EpoR when phosphorylated at Tyr485.

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Erythropoietin Receptor, phosphorylated (Tyr485) (EPOr)

Cat no: E3455-23B

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