ESR1 (6B6) Antibody

Cat no: 253058

Supplier: ABBIOTEC

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Description
Additional Information

Estrogen and progesterone receptors are members of a family transcription factors regulated by the binding of their cognate ligands. The interaction of hormone bound estrogen receptors with estrogen responsive elements (EREs) alters transcription of ERE-containing genes. The carbo, Xenopus/Amphibian,y terminal region of the estrogen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. Both have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B) which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors.

Catalogue number:	253058
Reactivities:	Human
Applications:	Immunofluorescence, Immunohistochemistry
Size:	0.1 ml
Accession:	P03372
Antigen:	Purified recombinant fragment of human ESR1 e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	6B6
Additional info:	Estrogen receptor; ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1; ESR1; ESR; NR3A1