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MtoZ Biolabs

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ESR1 (8H9A) Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 252823

ESR1 (8H9A) Antibody

Estrogen and progesterone receptors are members of a family transcription factors regulated by the binding of their cognate ligands. The interaction of hormone bound estrogen receptors with estrogen responsive elements (EREs) alters transcription of ERE-containing genes. The carbo, Xenopus/Amphibian,y terminal region of the estrogen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. Both have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B) which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors.

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SPECIFICATIONS

Catalog Number

252823

Size

0.1 ml

Applications

WB

Reactivities

Hum

Format

Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

P Type

Mouse Monoclonal Antibody

Antigen

Purified recombinant fragment of ESR1(aa130-339) e, Xenopus/Amphibian,pressed in E. coli.

Isotype

Mouse IgG1

Accession

P03372

Clonality

8H9A10

Additional Info

Zinc finger CCHC domain-containing protein 1; CSDD1; LIN28; ZCCHC1; LIN28A

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