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Estrogen Receptor, beta (ERb)

Estrogen Receptor, beta (ERb)

Cat no: E3565-16Z

Supplier: United States Biological
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Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Estrogen receptor (ER) was first cloned in 1987 and has been shown to be expressed and transcriptionally active in a number of tissues including ovary, testis, prostate and brain. Until recently, only the "classical" ER (ER alpha) has been known. However, a new estrogen binding receptor, referred to as ER beta, has recently been cloned in rat and humans. ER beta has been shown to be a high affinity estrogen binding protein capable of initiating transcription of genes under the control of estrogen response elements (ERE) Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Paraffin): 2-5ug/ml. Perform heat mediated antigen retrieval using citrate buffer. Immunohistochemistry (Frozen): 2-5ug/ml Western Blot: 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E3565-16Z
Reactivities: Human, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as liquid in PBS, 1mg/ml BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Immunoaffinity chromatography.
References: 1. Alves SE et al. (1998) Proc Natl Acad Sci USA 95:3281- 2. Duong, B. N., et al. (2006) AKT Regulation of Estrogen Receptor {beta} Transcriptional Activity in Breast Cancer, 66, 8373-8381.
Additional info: Recognizes human estrogen receptor (ER) beta at ~55kD. Species Crossreactivity: rat

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