Estrogen Receptor beta5 (ERb5)

Cat no: E3565-17Z

Supplier: United States Biological

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Eestrogen receptor beta 5 (ERB5), a splice variant of the nuclear receptor hormone ERbeta (ESR2), shown to exist in at least five isoforms (ERB1-ERB5). Although only the ERB1 variant appears fully functional, the remaining isoforms have been shown to form heterodimers with ERB1, thereby enhancing transcription. Immunohistochemical studies have revealed a ubiquitous expression of ERB5 in normal colorectal tissue, and to be present in all primary colorectal carcinomas studied (1). Studies also revealed the nuclear expression of ERB5 in the majority of breast carcinomas tested, with a possible association with improved patient survival (2). Applications: Suitable for use in Western Blot. and Immunohistochemistry Other applications not tested. Recommended Dilution: Immunohistochemistry (Paraffin): Requires antigen retrieval using sodium citrate buffer pH 6.0 heat treatment Optimal dilutions to be determined by the researcher. Positive Control: Normal colon or colon carcinoma Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	E3565-17Z
Reactivities:	Human
Hosts:	Mouse
Applications:	Western Blot
Size:	100ug
Form:	Supplied as a liquid in PBS, 0.09% sodium azide.
P type:	Mab
Isotype:	IgG1
Purity:	Purified by Protein G Chromatography.
References:	1. Wong, N. et al. (2005) ERbeta isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates. J. Pathol. 207: 53-60. 2. Shaaban, A.M. et al. (2008) Nuclear and cytoplasmic expression of ERbeta1, ERbeta2, and ERbeta5 identifies distinct prognostic outcome for breast cancer patients. Clin. Cancer Res. 14: 5228-5235.
Additional info:	Recognizes human estrogen receptor beta 5 (ERB5), a splice variant of the nuclear receptor hormone ERbeta (ESR2), shown to exist in at least five isoforms (ERB1-ERB5).

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Estrogen Receptor beta5 (ERb5)

Cat no: E3565-17Z

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