Estrogen-Related Receptor, gamma (ERRgamma, ERRg, ESRRG, ERR gamma-2, ERRG2, Estrogen Receptor-related Protein 3, ERR3, KIAA0832, Nuclear Receptor Subfamily 3 Group B Member 3, NR3B3)

Estrogen receptor-related receptor (ERR gamma), a NR3 Steroid Receptor, has been suggested to affect differentiation of the brain, heart, and kidney. ERR gamma binds as a monomer to an extended half-site of the ERRE type (TCAAGGTCA). ERR gamma has been shown to interact with PGC-1 alpha and has been implicated in the regulation of mitochondrial energy metabolism. In Humans, ERR gamma pre-mRNA undergoes extensive alternative splicing at the 5??? end, yielding at least six mRNA splice variants and two protein isoforms that differ by 23 amino acids in the N terminus. ERR gamma has been shown to be overexpressed in breast tumors, and its expression is correlated with levels of ErbB4, a likely indicator of preferred clinical course. As a result, ERR gamma has been suggested to be a potential biomarker for favorable clinical course and, possibly, hormonal sensitivity, and as a candidate target for therapeutic development. ERR gamma expression at the mRNA and protein levels is isoform- and tissue-specific in Humans. ERR gamma expression has been documented in Human heart, brain, placenta, skeletal muscle, kidney, pancreas, spleen, prostate, testis, and small intestine. ESTs have been isolated from Human tissue libraries, including cancerous fetus, uterus, lung, breast, head/neck, colon, skin, eye, adrenal, and breast, and normal placenta, kidney, brain, eye, pineal, ear, and heart.\n\nApplications: \nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 34-68ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHuman Breast cancer\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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