ETV4 (1A2G) Antibody

ETV4 (Ets variant gene 4), also known as PEA3. Several members of the Ets gene family are known to encode sequence specific DNA binding proteins. These include mouse PU.1,Mouse,ouse and human Ets-1, Drosophila E74, chicken and human Ets-2 and rat GABP-?. Each of these proteins recognizes similar motifs in DNA that share a centrally located 5'-GGAA-3' element. For instance,PorcineEA3 binds the motif 5'-AGGAAG-3' (the PEA-3 motif), but does not bind to the sequence 5'-AGGAAC-3', recognized by PU.1, although PU.1 binds equally well to both sequences. It appears that\r all of the Ets proteins recognize the same central core sequence but that each protein interacts with unique sequences that flank this core. PEA3 is e, Xenopus/Amphibian,pressed at readily detectable levels in cells of epithelial and fibroblastic origin but is not e, Xenopus/Amphibian,pressed in hematopoietic cells. This is in contrast to other members of the Ets gene family, such as Ets-1, Ets-2 and Fli-1, each of which is e, Xenopus/Amphibian,pressed primarily in cells of hematopoietic origin.

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SPECIFICATIONS

Catalog Number

252793

Size

0.1 ml

Applications

WB

Reactivities

Hum

Format

Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

P Type

Mouse Monoclonal Antibody

Antigen

Purified recombinant fragment of human ETV4 (aa50-109) e, Xenopus/Amphibian,pressed in E. coli.

Isotype

Mouse IgG1

Accession

P43268

Clonality

1A2G3

Additional Info

ETS translocation variant 4; Adenovirus E1A enhancer-binding protein; E1A-F; Polyomavirus enhancer activator 3 homolog; Protein PEA3; E1AF; PEA3; ETV4