Extracellular vesicles (EVs), prevalent in a multitude of body fluids and cell culture supernatants, are secreted by most cellular types. These include exosomes, which are diminutive vesicles characterized by a lipid bilayer with diameters ranging from 50 to 150 nm. The genesis of exosomes involves several stages: invagination of the plasma membrane, endosome formation, progression to multivesicular bodies (MVBs), and eventual extracellular release.
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