All cells release extracellular vesicles (EVs) as crucial part of their normal physiological activities. There are mainly two types of EVs: ectosomes and exosomes. Ectosomes, including microvesicles, microparticles, and large vesicles in the size range of of 50 nm to 1 ?m in diameter, pinch off the surface of the plasma membrane via outward budding. Exosomes, with diameters ranging from 40 nm to 160 nm (average around 100 nm), derive from endosomes. Plasma membranes invaginate to form multivesicular bodies,
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