Exosome (EX) is a heterogeneous group of extracellular vesicle (EV) with size similar to viruses (30-150 nm). Many different cell types, including red blood cells, B cells, T cells, mast cells, platelets, endothelial cells, fibroblasts, adipocytes, epithelial cells, muscle, dendritic cells, and tumor cells, can release EX. The heterogeneous vesicle is exclusively formed by the fusion of multivesicular bady formed by the inward budding of the endosomal membrane with the plasma membrane, which are then ......