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Exportin-4 (Exp4, XPO4, KIAA1721)

Exportin-4 (Exp4, XPO4, KIAA1721)

Cat no: E9009-34A

Supplier: United States Biological
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Nuclear transport receptors of karyopherin:importin-beta superfamily mediate various transport pathways between nucleus and cytoplasm. Exportin-4 is a novel mammalian member of this family. It is a RanGTP-binding protein consisting of N-terminal RanGTP-binding motif. It functions as a nuclear export receptor for eIF-5A and also might function as an export adapter in RNA export. It is also involved in nuclear export of Smad3 and regulation of Smad signaling. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Jurkat cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E9009-34A
Reactivities: Human, Mouse, Rat, Canine, Chicken/Bird
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity Chromatography.
References: 1. Lipowsky et.al EMBO J 19 (16) 4362-4371 (August 15, 2000) 2. Kurisaki et.al MCB 26 (4) 1318-1332 (February 2006).
Additional info: Recognizes human Exportin-4. Species Crossreactivity: chicken, chimpanzee, canine, mouse, rat, rhesus monkey. Species sequence homology: bovine, xenopus, zebrafish.

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