Ezh2 (Enhancer of Zeste Homolog 2, Polycomb group (PcG) Protein, ENX-1, EZH1, MGC9169)

EZH2, also known as ENX-1, is ubiquitously expressed during early embryo genesis, and becomes restricted to the central and peripheral nervous systems and sites of fetal hematopoiesis during later development. In the adult, EZH2 is restricted to the spleen, testis and placenta. The human EZH2 gene was originally mapped to chromosome 212, but further studies showed that this is a pseudogene, and that EZH2 actually maps to chromosome 7q35 within the critical region for malignant myeloid disorders. \nEZH2 and BMI-1 genes are co-expressed in Reed-Sternberg cells of Hodgkin

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SPECIFICATIONS

Catalog Number

E9085-02

Size

250ul

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.1% sodium azide.

P Type

Pab

Purity

Purified from rabbit antisera.

Isotype

IgG

References

1. Hobert, O., et al., Mol. Cell Biol. 16: 3066-3073 (1996). 2. Chen, H., et al., Genomics 38: 30-37 (1996). 3. Sewalt, R.G., et al., Mol. Cell Biol. 18: 3586-3595 (1998). 4. van Lohuizen, M., et al., Mol. Cell Biol. 18: 3572-3579 (1998). 5. Cardoso, C., et al., Eur. J. Hum. Genet. 8: 174-180 (2000). 6. Raaphorst, F.M., et al., Am. J. Pathol. 157: 709-715 (2000). 7. van Kemenade, F.J., et al., Blood 97: 3896-3901 (2001). 8. Sellers, W.R., et al., Cancer Cell 2: 349-350 (2002). 9. Varambally, S., et al., Nature 419: 624-629 (2002). 10. Kleer, C.G., et al., PNAS 100: 11,606-11,611 (2003).

Additional Info

Recognizes human EZH2.