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Ezrin, phosphorylated (Thr566) (Cytovillin, Villin-2, p81, EZR, VIL2)

Ezrin, phosphorylated (Thr566) (Cytovillin, Villin-2, p81, EZR, VIL2)

Cat no: E9100-25F

Supplier: United States Biological
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Ezrin is a member of the ERM family (ezrin, radixin, moesin) of proteins that link the cell membrane to the actin cytoskeleton and that are involved in cytoskeletal organization, cell motility and morphogenesis. The protein (586aa) consists of three domains: a membrane-binding aminoterminal domain, an extended alpha-helical domain, and a carboxyterminal domain that has an actin-binding site. Aberrantly high ezrin protein expression has been detected in the stromal cells of hemangioblastoma. Moreover, a high ezrin expression level is associated with immortalization and the increased proliferation rate of cells in vitro. It appears to play a role in the progression of tumors, such as the metastasis of osteosarcoma. Human Ezrin gene is localized to the end of the long arm of chromosome 6 (6q22-q27). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Positive Control: A431 cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: E9100-25F
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Turunen, OT. et al. J. Cell. Biol. 126:1445-1445 (1994). 2. Markku, K. et al. Hum. Genet. 103:662-665 (1998).
Additional info: Recognizes human Ezrin, phosphorylated at Thr566. Species Crossreactivity: mouse and rat.

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