Home  >  Products  >  F-Amidine

F-Amidine

Cat no: 011920


Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6uM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350uM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1uM, respectively).
Catalogue number: 011920
Size: 2.5mg
Alternative names: N-[(1S)-1-(Aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]benzamide;
References: Jones, J.E. et al.: Curr. Opin. Drug Discov. Dev., 12, 616 (2009); Hill, J.A. et al.: J. Immunol., 171, 538 (2003); Luo, Y. et al.: Biochemistry, 45, 11727 (2006); Knuckley, B. et al.: Biochemistry, 49, 1 (2010); Slack, J.L. et al.: Cell. Mol. Life Sci., 68, 709 (2011);

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*

Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave