F11, ID (F11, Coagulation factor XI, Plasma thromboplastin antecedent, Coagulation factor XIa heavy chain, Coagulation factor XIa light chain)

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq].\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\nImmunohistochemistry: 1:50-100\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

035295

Size

200ul

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)\nWong, P.C., et al. Thromb. Haemost. 104(2):302-310(2010)\nWhelihan, M.F., et al. J. Thromb. Haemost. 8(7):1532-1539(2010)\nDelluc, A., et al. Thromb. Haemost. 103(6):1161-1169(2010)\nBarber, M.J., et al. PLoS ONE 5 (3), E9763 (2010) :

Additional Info

Human

Alternative Names

F11, Coagulation factor XI, Plasma thromboplastin antecedent, Coagulation factor XIa heavy chain, Coagulation factor XIa light chain