FABP2 (Fatty acid-binding protein 2, Intestinal-type fatty acid-binding protein)

FABP 2, Fatty acid-binding protein 2, is a protein that in humans is encoded by the FABP2 gene. Using a human cDNA probe, the gene is assigned to chromosome 4 in somatic cell hybrids. FABP 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. The FABPs belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation.\n\nUniProt Number:\nP12104\n\nGene ID:\nFABP2\n\nApplications:\nSuitable for use in Western Blot.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Handling:\nStore at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term.\nAvoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

144499

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Baier, L. J., Sacchettini, J. C., Knowler, W. C., Eads, J., Paolisso, G., Tataranni, P. A., Mochizuki, H., Bennett, P. H., Bogardus, C., Prochazka, M.An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.J. Clin. Invest. 95: 1281-1287, 1995.\n2. Georgopoulos, A., Aras, O., Tsai, M. Y.Codon-54 polymorphism of the fatty acid-binding protein 2 gene is associated with elevation of fasting and postprandial triglyceride in type 2 diabetes.J. Clin. Endocr. Metab. 85: 3155-3160, 2000.\n3. Sparkes, R. S., Mohandas, T., Heinzmann, C., Gordon, J. I., Klisak, I., Zollman, S., Sweetser, D. A., Ragunathan, L., Winokur, S., Lusis, A. J.Human fatty acid binding protein assignments intestinal to 4q28-4q31 and liver to 2p11. (Abstract)Cytogenet. Cell Genet. 46: 697 only, 1987.\n

Additional Info

Recognizes human, mouse and rat FABP2. No crossreactivity with other proteins.