Factor XIII is the zymogenic form of the glutaminyl-peptide-g-glutamyl transferase factor XIIIa (fibrinoligase, plasma transglutaminase, fibrin stabilizing factor), found in both extracellular plasma and intracellular platelets, megakaryocytes, monocytes, placenta, uterus, prostate and liver tissues. Plasma Factor XIII is synthesized in the liver and circulates as a tetramer (Mr 320,000).
Factor XIII exists in plasma as a 340kD tetramer at a concentration of 10mg/L. In this form it is known as Factor XIII (a2b2), this nomenclature reflects its structure, a tetramer of two pairs of identical chains held together by non-covalent bands. The Factor VIII Zymogen is activated by thrombin, resulting in the formation of two dimers. Factor VIII-A (a2 dimer) which has fibrin stabilizing activity by the catalysis of covelent bridges between fibrin monomers is the presence of calcium. Factor VIII-S (b2 dimer) the biological role of which is unknown.
Applications:
Suitable for use in ELISA. Other applications not tested
Recommended Dilution:
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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