Factor XIII in both reduced and non-reduced forms. It does not react with human Factor XIII B-chain or human Factor XII. Factor XIII is a b-globulin found in plasma and is composed of two subunits. Factor XIII-A is the catalytic subunit and is a dimer with the molecular weight of 160kD. Factor XIII is present in plasma as a a2b2 heterodimer with the molecular weight of 320kD. Whereas in platelets, Factor XII is found to exists as a a2 unit. Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping, with the reported ability to identify capillary hemangiomas and tumors of the central nervous system.
Applications:
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Western Blot: 1-2ug/ml for 2hr, RT
Immunohistochemistry(Formalin fixed paraffin embedded): 1:50 for 30min at RT
Optimal dilutions to be determined by the researcher.
Positive Control:
Recombinant human Factor XIII A subunit, capillary hemangioma, dermatofibroma, placenta
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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