FADD Antibody

Cat no: 251168

Supplier: ABBIOTEC

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Description
Additional Information

FAS-associated death domain protein (FADD) is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling comple, Xenopus/Amphibian, (DISC) performs caspase-8 proteolytic activation. FADD is involved in interferon-mediated antiviral immune response,Porcinelaying a role in the positive regulation of interferon signaling. Defects in FADD are the cause of recurrent infections associated with encephalopathy hepatic dysfunction and cardiovascular malformations (IEHDCM). IEHDCM is a condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4-CD8-TCR-alpha-beta+ T-cell counts, and elevated IL10 and FASL levels.

Catalogue number:	251168
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	Q13158
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within human FADD.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	FADD; Protein FADD; Fas-associated protein with death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Mediator of receptor induced to, Xenopus/Amphibian,icity; Growth-inhbiting gene 3 protein; MORT1