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FADD, phosphorylated (Ser194) (Fas-Associated Death Domain Protein, MORT1)

FADD, phosphorylated (Ser194) (Fas-Associated Death Domain Protein, MORT1)

Cat no: F0019-53E

Supplier: United States Biological
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Fas-associating protein with death domain (FADD) is an adaptor protein involved in the apoptosis induced by Fas and TNF-R1, and mitogen induced cell proliferation (1). FADD consists of death domain (DD) at the C-terminal and death effector domain (DED) at the N-terminal (2). DD interacts with Fas and TNF-R1, which exposes the DED portion on the FADD. Unmasked DED binds to the DED of pro-caspase-8, which activates the cysteine protease cascade (3). The development of autoimmune lymphoproliferative (lpr) diseases has been linked to inactivation of Fas-FADD interaction (4). Also, the deficiency in FADD can inhibit TRAIL-induced cell apoptosis. Applications: Suitable for use in Western Blot, Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 1:500 Immunoprecipitation: 1:30 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: F0019-53E
Reactivities: Human
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Imtiyaz HZ et al, I J. Biol. Chem., Vol. 280, Issue 36, 31360-31367, 2005. 2. Chinnaiyan AM et al. Cell 81, 505
Additional info: Recognizes human FADD when phosphorylated at Ser194.

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